Anisopoikilocytosis – RBC Anomaly Details

Appearance The majority of RBCs vary greatly in shape and size, displaying irregular edges, varying sizes, membrane projections and fragments. Some RBCs are rod-shaped or may resemble bowling pins. Target cells are usually also present.…

Cloud Patterns – RBC Anomaly Details

Appearance RBCs with indentations appearing similar to cloud drawings. These may appear as a ‘ridge’, affecting many RBCs over a large area in the sample or as single RBCs. Fibrin clusters may be observed surrounding…

Aggregation – RBC Anomaly Details

Appearance Large numbers of RBCs randomly piled on top of one another. Also referred to as clumping or ‘blood sludge’ as the cells are severely agglutinated. Erythrocyte aggregation can be distinguished from rouleau in that…

Spherocytes – RBC Anomaly Details

Appearance Spherocytes are small, spherical RBCs, approximately two-thirds the diameter of normal RBCs and lack a zone of central pallor. They appear significantly darker and smaller than normal RBCs in brightfield and have a thicker…

Target Cells – RBC Anomaly Details

Appearance The term “target cell” arises from the cell’s resemblance to a target. Also referred to as codocytes and anulocytes, these cells range from hypochromic cells, where the central area of pallor is much larger…

Rouleau – RBC Anomaly Details

Appearance Rouleau is French for ‘rolls’. The term describes the appearance of red blood cells (RBCs) in this condition, forming strings of overlapping RBCs stacked on top of one another. Relevance At the periphery of…